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Wham is designed for paired-finish Illumina libraries with standard insert measurements (~300bp-500bp). Wham integrates mate-pair mapping, break up read through mapping, delicate-clipping, alternate alignment and consensus sequence based evidence to forecast SV breakpoints with one-nucleotide accuracy. Wham generates a put together pileup (catalog

The delicate-clipped sequences that overhang the breakpoint are collapsed right into a consensus sequence utilizing a several sequence alignment (MSA) supplied while in the seqAn library [27]. Wham applies a few filters for the consensus sequences. Breakpoints aren't described in cases exactly where consensus sequences are shorter than ten bp or co